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ThPOK Monoclonal Antibody (2POK), PE, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
$424.00
Specifications
| Antigen | ThPOK |
|---|---|
| Clone | 2POK |
| Concentration | 0.2 mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-112-2355
|
Invitrogen™
12592882 |
100 μg |
Each of 1 for $424.00
|
|
|||||
Description
Description: This 2POK monoclonal antibody reacts with mouse ThPOK, which is also known as c-Krox and Zbtb7b. In hematopoietic cells, this 78 kDa transcription factor is expressed in thymocytes and T lymphocytes in the spleen and lymph nodes. In non-hematopoietic cells, ThPOK can be detected in the skin, heart, smooth muscle, and liver. Studies demonstrate that ThPOK promotes CD4+ lineage differentiation by inhibiting the expression of CD8 lineage-specific genes such as Runx3. ThPOK has also been shown to inhibit Cd4 silencing, another key facet required for differentiation to the CD4+ lineage. In addition to its role in thymocyte development, ThPOK is involved in the effector functions of invariant natural killer T (iNKT) cells and gamma delta T cells. Applications Reported: This 2POK antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 2POK antibody has been tested by intracellular staining and flow cytometric analysis of mouse thymocytes using the Foxp3/Transcription Factor Staining Buffer Set (cat. 00-5523) and protocol. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g., COL1A1; MIM 120150) and has a role in development.Specifications
| ThPOK | |
| 0.2 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| Q64321 | |
| Zbtb7b | |
| Primary | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Zbtb7b |
| 2POK | |
| Flow Cytometry | |
| PE | |
| Rat | |
| Mouse | |
| 22724 | |
| IgG2a κ | |
| Affinity chromatography | |
| Antibody |
For Research Use Only.
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