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Thyroglobulin Antibody (2H11), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP233070A70 Shop All R&D Systems Products
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NP233070A70 0.1 mL
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Catalog No. NP233070A70 Supplier Novus Biologicals Supplier No. NBP233070AF750
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Description

Mouse Monoclonal Antibody

Thyroglobulin Monoclonal specifically detects Thyroglobulin in Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Thyroglobulin
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 2H11
Conjugate Alexa Fluor 750
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias AITD3TGN, TDH3, Tg, thyroglobulin
Gene Symbols TG
Host Species Mouse
Immunogen Human thyroid follicular cells were used as immunogen to generate the antibody.
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cancer, Cell Biology
Primary or Secondary Primary
Gene ID (Entrez) 7038.0
Test Specificity monoclonal antibody 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by monoclonal antibody 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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