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Thyroglobulin Mouse, Clone: SPM221, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2329040.2MG

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Catalog No. NBP232904B

This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Thyroglobulin Monoclonal antibody specifically detects Antigen in Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry (Paraffin), Western Blotting.
Specifications

Specifications

Thyroglobulin
SPM221
Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry-Paraffin 0.5-1.0ug/ml
P01266
AITD3TGN, TDH3, Tg, thyroglobulin
Mouse
IgG1 Kappa
0.2 mg
Cancer, Cell Biology
Primary
7038
Human, Mouse, Rat
Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin)
Unconjugated
PBS with 0.05% BSA. with 0.05% Sodium Azide
Purified
TG
Human thyroid follicular cells
Protein A purified
RUO
Store at 4C.
Monoclonal
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Documents
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