TIA1 Antibody (TIA1/1313), Alexa Fluor™ 750, Novus Biologicals™

Catalog No.	Quantity
NB008181	0.1 mL

Catalog No. NB008181 Supplier Novus Biologicals Supplier No. NBP254406AF750

Description

Mouse Monoclonal Antibody

TIA1 Monoclonal specifically detects TIA1 in Human samples. It is validated for Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Flow (Intracellular).

Specifications

• Antigen: TIA1
• Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Classification: Monoclonal
• Clone: TIA1/1313
• Conjugate: Alexa Fluor 750
• Dilution: Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Flow (Intracellular)
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Alias: cytotoxic granule-associated RNA-binding protein, nucleolysin TIA-1 isoform p40, p40-TIA-1, p40-TIA-1 (containing p15-TIA-1), RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA-1, TIA1 cytotoxic granule-associated RNA binding protein, TIA1 cytotoxic granule-associated RNA-binding protein
• Gene Symbols: TIA1
• Host Species: Mouse
• Immunogen: Recombinant human TIA1 fragment of 102 amino acid residues (aa279-380) (Uniprot: P31483)
• Purification Method: Protein A purified
• Quantity: 0.1 mL
• Regulatory Status: RUO
• Research Discipline: Adaptive Immunity, Apoptosis, Immunology
• Primary or Secondary: Primary
• Test Specificity: TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
• Target Species: Human
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG2b κ