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TIA1 Mouse anti-Human, Clone: TIA1/1313, Novus Biologicals™
SDP

Catalog No. NBP247642B Shop All R&D Systems Products
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0.2 mg
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NBP247642B 0.2 mg
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Catalog No. NBP247642B Supplier Novus Biologicals Supplier No. NBP2476420.2MG

Description

Mouse Monoclonal Antibody

TIA1 Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Immunofluorescence, Western Blotting.

Specifications

Antigen TIA1
Applications Western Blot, Flow Cytometry, SDS-Page, Immunofluorescence
Classification Monoclonal
Clone TIA1/1313
Conjugate Unconjugated
Dilution Western Blot 1-2ug/ml, Flow Cytometry 0.5-1ug/million cells in 0.1ml, SDS-Page, Immunofluorescence 1-2ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias cytotoxic granule-associated RNA-binding protein, nucleolysin TIA-1 isoform p40, p40-TIA-1, p40-TIA-1 (containing p15-TIA-1), RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA-1, TIA1 cytotoxic granule-associated RNA binding protein, TIA1 cytotoxic granule-associated RNA-binding protein
Gene Symbols TIA1
Host Species Mouse
Immunogen Recombinant human TIA1 fragment of 102 amino acid residues (aa279-380)
Molecular Weight of Antigen 40 kDa
Purification Method Protein A purified
Quantity 0.2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7072
Test Specificity TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tum
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG κ
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