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  6. Invitrogen™ TIGIT Recombinant Mouse Monoclonal Antibody (MBSA43), Alexa Fluor™ Plus 647, Invitrogen™ 

Invitrogen™ TIGIT Recombinant Mouse Monoclonal Antibody (MBSA43), Alexa Fluor™ Plus 647, Invitrogen™

Catalog No. p-200020022
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Catalog No. Quantity
50-252-9354 20 μg
74-001-0MP647 50 μg
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Catalog No. 50-252-9354 Supplier Invitrogen™ Supplier No. 740010MP64720UG
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Description

Mouse Recombinant Monoclonal Antibody

TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIGIT
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone MBSA43
Concentration 1.0 mg/mL
Conjugate Alexa Fluor Plus 647
Formulation Proprietary buffer with 0.008% Bromonitrodioxane, 0.008% Methylisothiazolone; pH 6.5
Gene TIGIT
Gene Accession No. Q495A1
Gene Alias ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Gene Symbols TIGIT
Host Species Mouse
Purification Method Protein A/G
Quantity 20 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 201633
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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