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TIMP-3, Rabbit anti-Human,Bovine,Canine,Equine,Sheep, Alexa Fluor 350, Polyclonal, Novus Biologicals™
SDP

Catalog No. NB005624 Shop All R&D Systems Products
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NB005624 0.1 mL
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Catalog No. NB005624 Supplier Novus Biologicals Supplier No. NBP233098AF350

Description

Rabbit Polyclonal Antibody

TIMP-3 Polyclonal specifically detects TIMP-3 in Human, Mouse, Rat, Bovine, Canine, Equine samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen TIMP-3
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Alexa Fluor 350
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias HSMRK222, K222, K222TA2, metalloproteinase inhibitor 3, MIG-5 protein, Protein MIG-5, pseudoinflammatory), SFD, TIMP metallopeptidase inhibitor 3, TIMP-3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, Tissue inhibitor of metalloproteinases 3
Gene Symbols TIMP3
Host Species Rabbit
Immunogen A portion of amino acids 175-211 of human TIMP3 was used as immunogen for this antibody.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Angiogenesis, Apoptosis, Cancer, Hypoxia, Metastasis, Vision
Primary or Secondary Primary
Test Specificity TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Target Species Human, Bovine, Canine, Equine, Sheep
Content And Storage Store at 4°C in the dark.
Isotype IgG
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