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Tocris Bioscience™ TMI 1, >98%
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Catalog No. 596010
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Catalog No. Quantity
59-601-0 10 mg
59-605-0 50 mg
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Catalog No. 59-601-0 Supplier Tocris Bioscience™ Supplier No. 5960/10
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Description

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Adam 17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.

Chemical Identifiers

CAS 287403-39-8
Molecular Formula C17H22N2O5S2

Specifications

Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 20mM in ethanol
Formula Weight 398.49
Purity >98%
Molecular Weight (g/mol) 398.492
Chemical Name or Material (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide

Safety and Handling

Recommended Storage Store at -20°C
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