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TMI 1, >98%, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
287403-39-8
C17H22N2O5S2
398.492
CVZIHNYAZLXRRS-HNNXBMFYSA-N
tmi-1,3s-4-4-but-2-ynyloxy phenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide,ih6,3s-4-4-but-2-yn-1-yloxy benzenesulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide,1zxc,tmi 1,tmi hplc,3s-4-4-but-2-ynoxyphenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide,3s-4-4-2-butyn-1-yloxy phenyl sulfonyl-n-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide,3s-4-4-but-2-yn-1-yloxy benzene sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
5288615
(3S)-4-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CC#CCOC1=CC=C(C=C1)S(=O)(=O)N2CCSC(C2C(=O)NO)(C)C
This item is not returnable. View return policy
287403-39-8
C17H22N2O5S2
398.492
CVZIHNYAZLXRRS-HNNXBMFYSA-N
tmi-1,3s-4-4-but-2-ynyloxy phenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide,ih6,3s-4-4-but-2-yn-1-yloxy benzenesulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide,1zxc,tmi 1,tmi hplc,3s-4-4-but-2-ynoxyphenyl sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide,3s-4-4-2-butyn-1-yloxy phenyl sulfonyl-n-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide,3s-4-4-but-2-yn-1-yloxy benzene sulfonyl-n-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
5288615
(3S)-4-(4-but-2-ynoxyphenyl)sulfonyl-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
CC#CCOC1=CC=C(C=C1)S(=O)(=O)N2CCSC(C2C(=O)NO)(C)C

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Adam 17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.
Quantity 50mg
Linear Formula C17H22N2O5S2
Solubility Information Soluble to 100mM in DMSO and to 20mM in ethanol
Formula Weight 398.49
Grade >98%
Chemical Name or Material (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide

Recommended Storage : Store at −20°C