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TNF-alpha Mouse, Clone: SPM543, Novus Biologicals™
SDP

Catalog No. NBP234372F Shop All R&D Systems Products
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NBP234372F 0.02 mg
NBP234372A 0.1 mg
NBP234372B 0.2 mg
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Catalog No. NBP234372F Supplier Novus Biologicals Supplier No. NBP2343720.02MG
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Description

Mouse Monoclonal Antibody has been used in 4 publications

TNF-alpha Monoclonal specifically detects TNF-alpha in Human, Mouse, Rat, Canine, Feline, Rabbit, Zebrafish samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen TNF-alpha
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Classification Monoclonal
Clone SPM543
Conjugate Unconjugated
Dilution Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunohistochemistry-Paraffin 1-2ug/ml, Immunohistochemistry-Frozen 1-2ug/ml
Formulation PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Accession No. P01375
Gene Alias APC1 protein, Cachectin, DIF, TNF, monocyte-derived, TNF-a, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Gene Symbols TNF
Host Species Mouse
Immunogen A hexadecapeptide corresponding to aa115-130 of human TNF-alpha, conjugated to thyroglobulin
Molecular Weight of Antigen 17 kDa
Purification Method Protein A purified
Quantity 0.02 mg
Regulatory Status RUO
Research Discipline Adaptive Immunity, Asthma, Autophagy, Biologically Active Proteins, Cancer, Cytokine Research, Diabetes Research, Immune System Diseases, Immunology, Innate Immunity
Primary or Secondary Primary
Gene ID (Entrez) 7124
Test Specificity Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Target Species Human, Mouse, Rat, Canine, Feline, Rabbit, Zebrafish
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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