TNNC1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8791	Proteintech Group Inc 135041AP150UL	150 μL

Description

Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). In response to beta-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC (1-3).

Specifications

• Antigen: TNNC1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P19123, P63316
• Gene ID (Entrez): 21924, 290561, 7134
• Immunogen: TNNC1 Fusion Protein Ag4339
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TNNC1

• Concentration: 0.57 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CMD1Z, TN C, TNC, TNNC, TNNC1, troponin C type 1 (slow)
• Gene Symbols: Tnnc1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody