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TOX3 Antibody (TOX3/1123), DyLight 594, Novus Biologicals™
SDP

Catalog No. NB007239 Shop All R&D Systems Products
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NB007239 0.1 mL
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Catalog No. NB007239 Supplier Novus Biologicals Supplier No. NBP247748DL594
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Description

Mouse Monoclonal Antibody

TOX3 Monoclonal specifically detects TOX3 in Human, Chicken samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

Antigen TOX3
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone TOX3/1123
Conjugate DyLight 594
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias CAG trinucleotide repeat-containing gene F9 protein, CAGF9trinucleotide repeat containing 9, TNRC9, TOX high mobility group box family member 3, Trinucleotide repeat-containing gene 9 protein
Gene Symbols TOX3
Host Species Mouse
Immunogen Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary) (Uniprot: O15405)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
Target Species Human, Chicken
Content And Storage Store at 4°C in the dark.
Isotype IgG2b κ
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