TOX3 Antibody (TOX3/1123), Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2451650.2MG

Catalog No. NBP24516502

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

TOX3 Monoclonal antibody specifically detects TOX3 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, SDS-Page, Immunofluorescence.

Specifications

• Antigen: TOX3
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
• Gene Accession No.: O15405
• Gene Symbols: TOX3
• Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 27324
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
• Clone: TOX3/1123
• Conjugate: Unconjugated
• Formulation: 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: CAG trinucleotide repeat-containing gene F9 protein, CAGF9trinucleotide repeat containing 9, TNRC9, TOX high mobility group box family member 3, Trinucleotide repeat-containing gene 9 protein
• Host Species: Mouse
• Molecular Weight of Antigen: 63 kDa
• Quantity: 0.2 mg
• Primary or Secondary: Primary
• Test Specificity: It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
• Content And Storage: Store at 4C.
• Isotype: IgG2b κ

For Research Use Only