TOX3 Antibody (TOX3/1123), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP24516500	Novus Biologicals NBP2451650.02MG	0.02 mg
NBP24516501	Novus Biologicals NBP2451650.1MG	0.1 mg
NBP24516502	Novus Biologicals NBP2451650.2MG	0.2 mg

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

TOX3 Monoclonal specifically detects TOX3 in Human, Chicken samples. It is validated for Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array, Immunofluorescence.

Specifications

• Antigen: TOX3
• Concentration: 0.2mg/mL
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: O15405
• Gene ID (Entrez): 27324
• Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.
• Molecular Weight of Antigen: 63 kDa

• Clone: TOX3/1123
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Formulation: 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: CAG trinucleotide repeat-containing gene F9 protein, CAGF9trinucleotide repeat containing 9, TNRC9, TOX high mobility group box family member 3, Trinucleotide repeat-containing gene 9 protein
• Gene Symbols: TOX3
• Isotype: IgG2b κ
• Purification Method: Protein A or G purified
• Test Specificity: It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

For Research Use Only