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Tocris Bioscience™ TP 064
Potent and selective PRMT 4 inhibitor
Supplier: Tocris Bioscience™ 6008/10
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Description
TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website..
Specifications
| TP 064 | |
| 10 mg | |
| C28H34N4O2 | |
| Solid | |
| Bioactive Small Molecule |
| N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide | |
| Soluble to 100mM in 1eq. HCl and to 100mM in DMSO | |
| 458.6 | |
| White | |
| >98% |
Safety and Handling
Recommended Storage : Store at -20°C
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