Tocris Bioscience™ TP 064, Tocris Bioscience™

Potent and selective PRMT 4 inhibitor

Supplier:  Tocris Bioscience™ 6008/10

Catalog No. 60-081-0

Description

TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.

To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website..

Specifications

• Chemical Name or Material: TP 064
• Quantity: 10 mg
• Molecular Formula: C₂₈H₃₄N₄O₂
• Physical Form: Solid
• Product Type: Bioactive Small Molecule

• Synonym: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
• Solubility: Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
• Formula Weight: 458.6
• Color: White
• Purity: >98%

Safety and Handling

Recommended Storage : Store at -20°C

For Research Use Only.