TP53BP1 Monoclonal Antibody (OTI6D9), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA806950

Catalog No. 50-168-1326

Description

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Specifications

• Antigen: TP53BP1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TP53BP1
• Gene Alias: 53BP1, TDRD30, TP53, p202, p53BP1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7158
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI6D9
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q12888
• Gene Symbols: TP53BP1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-300 of human TP53BP1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b