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  6. Transgelin/TAGLN/SM22 alpha Antibody (SPM606), Novus Biologicals™

Transgelin/TAGLN/SM22 alpha Antibody (SPM606), Novus Biologicals™
SDP

Catalog No. NBP24443601 Shop All R&D Systems Products
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NBP24443601 0.1 mg
NBP24443600 0.02 mg
NBP24443602 0.2 mg
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Catalog No. NBP24443601 Supplier Novus Biologicals Supplier No. NBP2444360.1MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Transgelin/TAGLN/SM22 alpha Monoclonal specifically detects Transgelin/TAGLN/SM22 alpha in Human, Mouse, Porcine, Bovine, Rabbit samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

Antigen Transgelin/TAGLN/SM22 alpha
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone SPM606
Concentration 0.2mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 1 - 2 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. Q01995
Gene Alias DKFZp686P11128, Protein WS3-10, SM2222 kDa actin-binding protein, SMCCDKFZp686B01212, Smooth muscle protein 22-alpha, TAGLN1, transgelin, transgelin variant 2, WS3-10SM22-alpha
Gene Symbols TAGLN
Host Species Mouse
Immunogen Recombinant full-length human transgelin (TAGLN) protein.
Molecular Weight of Antigen 22 kDa
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6876
Test Specificity This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Target Species Human, Mouse, Pig, Primate, Rabbit
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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