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Transglutaminase 2/TGM2 Antibody (SPM358) - IHC-Prediluted, Novus Biologicals™
SDP

Catalog No. NBP248084 Shop All R&D Systems Products
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NBP248084 7 mL
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Catalog No. NBP248084 Supplier Novus Biologicals Supplier No. NBP248084
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Description

Mouse Monoclonal Antibody

Transglutaminase 2/TGM2 Monoclonal specifically detects Transglutaminase 2/TGM2 in Human, Mouse, Rat, Monkey, Rabbit samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Transglutaminase 2/TGM2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPM358
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias C polypeptide, EC 2.3.2.13, G-ALPHA-h, protein-glutamine gamma-glutamyltransferase 2, protein-glutamine-gamma-glutamyltransferase, TG(C), TG2, TGase C, TGase H, TGase-2, TGase-H, TGCGNAH, Tissue transglutaminase, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), Transglutaminase C, Transglutaminase H, Transglutaminase-2
Gene Symbols TGM2
Host Species Mouse
Immunogen Recombinant full-length human Transglutaminase 2/TGM2 protein (Uniprot: P21980)
Purification Method Protein A or G purified
Quantity 7 mL
Regulatory Status RUO
Research Discipline Apoptosis, Immune System Diseases, Immunology, Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 7052
Test Specificity Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Target Species Human, Mouse, Rat, Monkey, Rabbit
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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