TRIB3 Mouse anti-Human, Mouse, Rat, Clone: 2C10C7, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 667021IG150UL

Catalog No. 50-173-7118

Description

A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.

Specifications

• Antigen: TRIB3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q8K4K2, Q96RU7, Q9WTQ6
• Gene Symbols: TRIB3
• Immunogen: TRIB3 Fusion Protein Ag25776
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: 2C10C7
• Conjugate: Unconjugated
• Gene: TRIB3
• Gene Alias: C20orf97, NIPK, SINK, SKIP3, TRB 3, TRB3, TRIB3, Tribbles homolog 3
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 228775, 246273, 57761
• Content And Storage: -20°C
• Form: Liquid