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Troglitazone, Tocris Bioscience™
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Catalog No. 311450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective PPARγ agonist; antidiabetic agent

Selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

Chemical Identifiers

CAS 97322-87-7
Molecular Formula C24H27NO5S
Molecular Weight (g/mol) 441.542
InChI Key GXPHKUHSUJUWKP-UHFFFAOYSA-N
Synonym troglitazone, rezulin, romglizone, prelay, romozin, noscal, rezulin tn, troglitazona, troglitazonum, ccris 8969
PubChem CID 5591
ChEBI CHEBI:9753
IUPAC Name 5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
SMILES CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O

Specifications

Quantity 50 mg
Formula Weight 441.54
Percent Purity 98%
Chemical Name or Material Troglitazone

Safety and Handling

Recommended Storage Store at -20°C
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