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TRPV6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7205400 Shop All Proteintech Group Inc Products
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50-172-8723 150 μL
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Catalog No. 50-172-8723 Supplier Proteintech Group Inc Supplier No. 134111AP150UL
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Description

Rabbit Polyclonal Antibody

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA). Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY. Interacts with calmodulin.

Specifications

Antigen TRPV6
Applications Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.49 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TRPV6
Gene Accession No. Q91WD2, Q9H1D0, Q9R186
Gene Alias ABP/ZF, Calcium transport protein 1, CaT L, CaT like, CAT1, CATL, ECAC2, Epithelial calcium channel 2, HSA277909, LP6728, TRPV6, ZFAB
Gene Symbols TRPV6
Host Species Rabbit
Immunogen TRPV6 Fusion Protein Ag4060
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114246, 55503, 64177
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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