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Tryptase alpha/beta 1 Antibody (TPSAB1/1961), Alexa Fluor™ 700, Novus Biologicals™
SDP

Catalog No. NB008881 Shop All R&D Systems Products
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NB008881 0.1 mL
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Catalog No. NB008881 Supplier Novus Biologicals Supplier No. NBP275754AF700
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Description

Mouse Monoclonal Antibody

Tryptase alpha/beta 1 Monoclonal antibody specifically detects Tryptase alpha/beta 1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin).

Specifications

Antigen Tryptase alpha/beta 1
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone TPSAB1/1961
Conjugate Alexa Fluor 700
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Accession No. Q15661
Gene Alias EC:3.4.21.59, epididymis secretory sperm binding protein, mast cell alpha II tryptase, mast cell beta I tryptase, mast cell tryptase, TPS1, TPS2, TPSB1, TPSB2, tryptase alpha II, Tryptase alpha-1, tryptase beta I, tryptase beta-1, Tryptase beta-2, Tryptase I, tryptase II, tryptase-1, tryptase-2, tryptase-I, tryptase-III
Gene Symbols TPSAB1
Host Species Mouse
Immunogen Recombinant human Tryptase alpha/TPS1 protein fragment (around aa 115-233) (Exact sequence is proprietary) (Uniprot: Q15661)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Immunology, metabolism
Primary or Secondary Primary
Test Specificity This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis. Due to sequence identity this antibody will likely cross react with tryptase beta 2.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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