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TTF-1/ NKX2-1 Antibody (SPM150), PE, Novus Biologicals™
SDP

Catalog No. NBP234742PE Shop All R&D Systems Products
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NBP234742PE 0.1 mL
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Catalog No. NBP234742PE Supplier Novus Biologicals Supplier No. NBP234742PE
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Description

Mouse Monoclonal Antibody

TTF-1 / NKX2-1 Monoclonal specifically detects TTF-1 / NKX2-1 in Human, Mouse, Rat samples. It is validated for Flow Cytometry.

Specifications

Antigen TTF-1 / NKX2-1
Applications Flow Cytometry
Classification Monoclonal
Clone SPM150
Conjugate PE
Dilution Flow Cytometry
Gene Alias benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2
Gene Symbols NKX2-1
Host Species Mouse
Immunogen Rat full length TTF-1/ NKX2-1 recombinant protein (Uniprot: P43699)
Molecular Weight of Antigen 40 kDa
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Membrane Trafficking and Chaperones
Primary or Secondary Primary
Gene ID (Entrez) 7080
Test Specificity Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Target Species Human, Mouse, Rat
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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