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Tyrosinase Antibody (SPM360), PerCP, Novus Biologicals™
SDP

Catalog No. NBP234770P Shop All R&D Systems Products
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NBP234770P 0.1 mL
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Catalog No. NBP234770P Supplier Novus Biologicals Supplier No. NBP234770PCP
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Description

Mouse Monoclonal Antibody

Tyrosinase Monoclonal specifically detects Tyrosinase in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen Tyrosinase
Applications Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPM360
Conjugate PerCP
Dilution Flow Cytometry
Gene Alias CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
Gene Symbols TYR
Host Species Mouse
Immunogen Recombinant tyrosinase protein (Uniprot: P14679 )
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Lipid and Metabolism
Primary or Secondary Primary
Gene ID (Entrez) 7299
Test Specificity Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This monoclonal antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this monoclonal antibody shows tyrosinase in melanotic as well as amelanotic variants. This monoclonal antibody is a useful marker for melanocytes and melanomas.
Target Species Human
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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