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UCH-L1/PGP9.5 Antibody (SPM575), DyLight 550, Novus Biologicals™
SDP

Catalog No. NBP234808R Shop All R&D Systems Products
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Catalog No. NBP234808R Supplier Novus Biologicals Supplier No. NBP234808R
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Mouse Monoclonal Antibody

UCH-L1/PGP9.5 Monoclonal specifically detects UCH-L1/PGP9.5 in Human, Mouse, Rat, Porcine, Bovine, Canine, Guinea Pig, Rabbit, Sheep, Zebrafish samples. It is validated for Western Blot, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen UCH-L1/PGP9.5
Applications Western Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone SPM575
Conjugate DyLight 550
Dilution Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen
Gene Alias EC 3.4.19.12, EC 6.-, Neuron cytoplasmic protein 9.5, PARK5, PGP 9.5, PGP9.5, PGP9.5Uch-L1, PGP95, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase), ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin C-terminal hydrolase, Ubiquitin thioesterase L1, UCHL1, UCH-L1
Gene Symbols UCHL1
Host Species Mouse
Immunogen UCH-L1/PGP9.5 protein from brain (Uniprot: P09936)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Alzheimers Research, Cellular Markers, Neurodegeneration, Neuronal Cell Markers, Neuroscience, Neurotransmission
Primary or Secondary Primary
Gene ID (Entrez) 7345
Test Specificity This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.
Target Species Human, Mouse, Rat, Pig, Bovine, Canine, Guinea Pig, Rabbit, Sheep, Zebrafish
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2a κ
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