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UCHL5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. p-7203837 Shop All Proteintech Group Inc Products
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50-172-7237 150 μL
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Catalog No. 50-172-7237 Supplier Proteintech Group Inc Supplier No. 115271AP150UL
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Description

Rabbit Polyclonal Antibody

UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFbeta-dependent gene expression by de-ubiquinating and stabilizing TGFbeta RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.

Specifications

Antigen UCHL5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene UCHL5
Gene Accession No. Q9WUP7, Q9Y5K5
Gene Alias CGI 70, INO80R, Ubiquitin thioesterase L5, UCH L5, UCH37, UCHL5
Gene Symbols UCHL5
Host Species Rabbit
Immunogen UCHL5 Fusion Protein Ag2095
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 360853, 51377, 56207
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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