UCHL5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-7237	Proteintech Group Inc 115271AP150UL	150 μL

Description

UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFbeta-dependent gene expression by de-ubiquinating and stabilizing TGFbeta RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.

Specifications

• Antigen: UCHL5
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q9WUP7, Q9Y5K5
• Gene ID (Entrez): 360853, 51377, 56207
• Immunogen: UCHL5 Fusion Protein Ag2095
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: UCHL5

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CGI 70, INO80R, Ubiquitin thioesterase L5, UCH L5, UCH37, UCHL5
• Gene Symbols: UCHL5
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody