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USP20/VDU2 Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7140705
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50-155-9490 20 μL
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Catalog No. 50-155-9490 Supplier Bethyl Laboratories, Inc Supplier No. A301189AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both ′Lys-48′- and ′Lys-63′-linked polyubiquitin chains.

Specifications

Antigen USP20/VDU2
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene USP20
Gene Accession No. Q8C6M1, Q9Y2K6
Gene Alias USP20; VDU2; ubiquitin specific protease 20; KIAA1003; pVHL-interacting deubiquitinating enzyme 2; ubiquitin specific peptidase 20; LSFR3A
Gene Symbols Usp20
Host Species Rabbit
Immunogen Between 863 and 913
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10868, 74270
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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