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USP5/IsoT Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501560651
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50-156-0651 100 μL
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Catalog No. 50-156-0651 Supplier Bethyl Laboratories, Inc Supplier No. A301542A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Specifications

Antigen USP5/IsoT
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene USP5
Gene Accession No. P45974, P56399
Gene Alias Ubiquitin carboxyl-terminal hydrolase 5; Ubiquitin thiolesterase 5; Ubiquitin-specific processing protease 5; Deubiquitinating enzyme 5; Isopeptidase T
Gene Symbols USP5
Host Species Rabbit
Immunogen Between 75 and 125
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22225, 8078
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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