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Tocris™ VO-OHpic

Potent PTEN inhibitor

Manufacturer:  Tocris™ 3591/50

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Catalog No. 35-915-0

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For Research Use Only



Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10µM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts.
  • Chemical Name: (OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen
  • Formula: C12H10N2O8V
  • CAS Number: 675848-25-6
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >98
Description & Specifications


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