VPS4B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-1714	Proteintech Group Inc 176731AP150UL	150 μL

Description

Class E vacuolar protein sorting (vps) proteins are necessary for appropriate sorting of receptors in the yeast endocytic pathway. The yeast Vps4p is a member of the AAA protein family (ATPases associated with diverse cellular activities) and plays an important role in transporting proteins out of a prevacuolar endosomal compartment. In human, two non-allelic orthologous proteins (VPS4A and VPS4B) of yeast Vps4p are known and can form heteromeric complexes with each other. Both VPS4 (also known as SKD1 in mouse) proteins are class E VPSs and are involved in intracellular protein trafficking, similar to Vps4p in yeast. A human CHMP1 protein, which is implicated in multivesicular body formation, physically interacts with VPS4. HIV-1 uses cellular machinery to bud from infected cells and requires VPS4 and TSG101/VPS23 for this budding process. Domit negative mutant of VPS4 inhibit vacuolar protein sorting and also arrest HIV-1 and MLV budding. Thus, retroviruses normally use the VPS pathway to form multivesicular bodies during the budding process.

Specifications

• Antigen: VPS4B
• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O75351, P46467
• Gene ID (Entrez): 20479, 360834, 9525
• Immunogen: VPS4B Fusion Protein Ag11610
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: VPS4B

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B
• Gene Symbols: Vps4b
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody