Potent and selective Lck and Src inhibitor; also inhibits SIK
Manufacturer: Tocris 5413/50
DescriptionPotent and selective Lck and Src inhibitor (IC50 values are 2 and 6nM respectively). Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885.
- Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
- Formula: C32H36N6O4
- CAS Number: 837422-57-8
- Solubility: Soluble to 100mM in DMSO
- Purity: >98