WRN Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-155-7176	100 μL

Catalog No. 50-155-7176 Supplier Bethyl Laboratories, Inc Supplier No. A300238A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predomit nucleolar localization. It possesses an intrinsic 3′ to 5′ DNA helicase activity, and is also a 3′ to 5′ exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Specifications

• Antigen: WRN
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: WRN
• Gene Accession No.: Q14191
• Gene Alias: DKFZp686C2056, RECQ3, RECQL2, RECQL3, DNA helicase, RecQ-like type 3; Werner syndrome ATP-dependent helicase; exonuclease WRN; recQ protein-like 2
• Gene Symbols: WRN
• Host Species: Rabbit
• Immunogen: Between 400 and 450
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7486
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG