Tocris™ WZ 4003

Potent and selective NUAK1/2 inhibitor

Manufacturer: Tocris™ 5177/10

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Catalog No. 51-771-0

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For Research Use Only


    Product Type WZ 4003
    Inhibitors WZ 4003
    Purity >98
    Molecular Weight 496.99
    Quantity 10mg

    Potent and selective NUAK1/2 inhibitor (IC50 values are 20 and 100nM respectively). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells.

    • Chemical Name: N-3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide
    • Formula: C25H29ClN6O3
    • CAS Number: 1214265-58-3
    • Solubility: Soluble to 50mM in 1eq. HCl and to 20mM in DMSO with gentle warming
    • Purity: >98

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