Tocris™ XAP 044

Potent and selective mGlu7 antagonist

Manufacturer: Tocris™ 5248/10

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Catalog No. 52-481-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type XAP 044
    Inhibitors XAP 044
    Purity >98
    Molecular Weight 380.13
    Quantity 10mg

    Potent and selective mGlu7 antagonist (IC50 = 88nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.

    • Chemical Name: 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
    • Formula: C15H9IO4
    • CAS Number: 196928-50-4
    • Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
    • Purity: >98

  • Description & Specifications

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