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Tocris Bioscience™ YC 1
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Catalog No. 430750
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50 mg
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Catalog No. Quantity
43-075-0 50 mg
43-071-0 10 mg
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Catalog No. 43-075-0 Supplier Tocris Bioscience™ Supplier No. 4307/50
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Description

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Chemical Identifiers

CAS 170632-47-0
Molecular Formula C19H16N2O2

Specifications

Quantity 50 mg
Formula Weight 304.34
Purity >99%
Molecular Weight (g/mol) 304.35
Chemical Name or Material YC 1

Safety and Handling

Recommended Storage Store at Room Temperature
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