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  5. Tocris Bioscience™ Z-Guggulsterone

Tocris Bioscience™ Z-Guggulsterone
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Catalog No. 357050R
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).

Specifications

Quantity 50 mg
Product Type Z-Guggulsterone
Purity >98%
Molecular Weight (g/mol) 312.45
Inhibitors Z-Guggulsterone

For Research Use Only

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