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  5. Tocris Bioscience™ Zoledronic Acid

Tocris Bioscience™ Zoledronic Acid
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Catalog No. p-7121040
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Quantity:
10 mg
50 mg
Catalog No. Quantity
61-111-0 10 mg
61-115-0 50 mg
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Catalog No. 61-111-0

Supplier: Tocris Bioscience™ 6111/10

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Description

Potent farnesyl diphosphate (FPP) synthase inhibitor

Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

Specifications

Chemical Name or Material Ras GTPase Inhibitors
CAS 118072-93-8
Synonym [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Quantity 10 mg
Solubility Soluble to 50mM in 1.1eq. NaOH and to 3mM in water
Molecular Formula C5H10N2O7P2
Formula Weight 272.09
Physical Form Solid
Color Off-white
Product Type Bioactive Small Molecule
Purity >98%
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