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Tocris Bioscience™ ZZL 7
GREENER_CHOICE

Catalog No. 789810
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS)

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier.

Specifications

Chemical Name or Material N-Acetyl-L-alanyl-L-valine methyl ester
CAS 99141-91-0
Quantity 10 mg
Target SLC6A4/5-HTTLPR/Serotonin transporter
Molecular Formula C11H20N2O4
Purity 0.98
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