Tocris Bioscience™ ZZL 7

Catalog No. 78-981-0

Supplier: Tocris Bioscience™ 7898/10

Description

Inhibitor of the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS)

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier.

Greener Choice Claims

• Environmental benefits include:
• Ozone-Safe or Safe for the Ozone Layer

Specifications

• Chemical Name or Material: N-Acetyl-L-alanyl-L-valine methyl ester
• CAS: 99141-91-0
• Quantity: 10 mg
• Target: SLC6A4/5-HTTLPR/Serotonin transporter
• Molecular Formula: C₁₁H₂₀N₂O₄
• Purity: 0.98