Short chains of amino acids linked by peptide (amide) bonds. Peptides are used as catalysts, signaling ligands, and imaging agents; for biometric hydrogel construction, immunoprecipitation processes, and more.
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An a2-AR antagonist (Kis 5 4 2 and 1 3 nM for a2A- a2B- and a2C-ARs respectively) reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats at 10 mg/kg
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An a2-AR antagonist (Kis 5 4 2 and 1 3 nM for a2A- a2B- and a2C-ARs respectively) reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats at 10 mg/kg
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An a-AR agonist binds to a1A- a1B- a1D- a2A- a2B- and a2C-ARs in a radioligand binding assay (IC50s 0 08 0 56 0 45 0 98 1 8 and 0 22 M respectively) increases intracellular calcium levels in HEK293 cells transfected with human a2B-ARs (EC50 99 M) but not other a-ARs a 5-HT1 receptor agonist (Kis 0 7 and 14 nM for the human 5-HT1D and 5-HT1B receptors respectively) inhibits forskolin-induced cAMP production in CHO Pro 5 cells expressing human 5-HT1D and 5-HT1B receptors by 62 and 49 respectively at 1 M induces contraction of isolated dog nasal mucosal blood vessels at 0 25 g/ml reduces nasal patency in dogs when administered topically or intravenously
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An a-AR agonist binds to a1A- a1B- a1D- a2A- a2B- and a2C-ARs in a radioligand binding assay (IC50s 0 08 0 56 0 45 0 98 1 8 and 0 22 M respectively) increases intracellular calcium levels in HEK293 cells transfected with human a2B-ARs (EC50 99 M) but not other a-ARs a 5-HT1 receptor agonist (Kis 0 7 and 14 nM for the human 5-HT1D and 5-HT1B receptors respectively) inhibits forskolin-induced cAMP production in CHO Pro 5 cells expressing human 5-HT1D and 5-HT1B receptors by 62 and 49 respectively at 1 M induces contraction of isolated dog nasal mucosal blood vessels at 0 25 g/ml reduces nasal patency in dogs when administered topically or intravenously
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A metabolite of glycine and precursor in the biosynthesis of creatine formed from glycine by GATM and methylated by GAMT to form creatine levels are altered in individuals with CCDSs
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An inhibitor of GlyT1 (IC50 3 nM) selective for GlyT1 over GlyT2 (IC50 10 UM) as well as over NMDA receptors and the inhibitory glycine receptor at 100 UM increases prefrontal cortical levels of glycine in rats at 10 mg/kg reverses MK-801-induced persistent latent inhibition in a mouse model of schizophrenia
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A glycine-site selective NMDA receptor antagonist selectively binds to the NMDA receptor glycine-binding site (IC50 0 56 UM) over the NMDA- quisqualate- and kainate-binding sites (IC50s 169 153 and 1000 UM respectively) induces antidepressant-like activity in a variety of behavioral tests in mice at 0 1 and 1 mg/kg
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An arachidonoyl amino acid isolated from both rat and bovine brain the glycine congener (NAGly Item No 90051) suppresses formalin-induced pain in rats but NAG-3H-ABA has not yet been fully characterized
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A synthetic compound made up of the arginine-glycine-aspartate motif used to inhibit integrin-ligand interactions in studies related to cell adhesion migration growth and differentiation also can directly induce apoptosis by activating pro-caspase-3
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