D-(+)-Trehalose is among the most effective sugars for the stabilization of proteins against damage caused by desiccation or freezing and is noted for its high water-retention capabilities, protecting cells against multiple environmental stressors. It is rarely used as a replacement for conventional sweeteners. It is more commonly used as a cryoprotectant in a variety of cell freezing media. A wide array of implemental enzymes, probes, substrates, antibodies and biology reagents can be kept in trehalose, saving on expensive freezer storage.D-(+)-Trehalose dihydrate is a non-reducing disaccharide, yielding 2 moles of D-glucose upon acid hydrolysis. It is an inducer of autophagy and has properties allowing it to stabilize partially unfolded proteins and inhibit protein aggregation.Trehalose dihydrate has been demonstrated to decrease lysosomal amyloid precursor protein (APP) and inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.