Carbohydrates
Apexbio Technology LLC HyperTrap Heparin FF Column 5ml
HyperTrap Heparin FF Column is an affinity chromatography medium designed for the purification of heparin-binding biomolecules The column exploits the strong ionic and specific interactions between immobilized heparin and target proteins such as growth factors coagulation factors and certain enzymes enabling selective retention and efficient separation from complex biological mixtures This tool is widely utilized in the isolation and characterization of heparin-binding proteins investigation of protein glycosaminoglycan interactions and purification of bioactive factors for downstream functional assays and structural analyses
Medchemexpress LLC D-3263 hydrochloride | 1008763-54-9 | MFCD22665741 | 98.0% | 409.95 | C21H32ClN3O3 | 10 MG
D-3263 hydrochloride is an enteric-coated, orally bioavailable agonist of transient receptor potential melastatin member 8 (TRPM8). It binds and activates TRPM8, modulates calcium and sodium flux, and has been investigated for potential antineoplastic effects and modulation of androgen-related pathways.
- Orally bioavailable TRPM8 agonist suitable for in vivo studies.
- Enteric-coated formulation for improved gastrointestinal stability.
- High purity (98.0%) supports reproducible experimental results.
- Soluble in DMSO and formulatable for common in vivo vehicles.
- Stable when stored sealed at 4°C; solvent stability at -80°C for extended storage.
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000097081.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 5mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
AdipoGen 3OH-C10-L-HSL
Chemical. CAS 192883-12-8. Formula C14H25NO4. MW 271.35. Synthetic. N-3-hydroxydecanoyl-L-homoserine lactone is a small diffusible signaling molecule secreted by various bacteria and involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. This lactone is produced via lactonolysis from 3-oxodecanoyl-homoserine lactone, altering quorum sensing or contributing to quorum quenching. The applications of this molecule include regulation of virulence and exoproteases.
Medchemexpress LLC Azido-PEG4-beta-D-glucose | 1609083-15-9 | 99.9% | 381.38 | 25 MG
Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. This click chemistry reagent contains an Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide functional group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Intended for research use only
Medchemexpress LLC UDP-3-O-acyl-GlcNAc | 108636-29-9 | 1 MG
UDP-3-O-acyl-GlcNAc is an E. coli metabolite involved in the 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway. It has a molecular weight of 833.71 and a chemical formula of C31H53N3O19P2. This product is for research use only.
- Molecular weight: 833.71
- Formula: C31H53N3O19P2
- Initial source: Microorganisms (Escherichia)
- For research use only
Apexbio Technology LLC Cyclosporin D 63775-96-2 25mg
Cyclosporin D (CAS 63775-96-2) is a structural analogue of Cyclosporin A with comparatively reduced immunosuppressive activity Mechanistically it weakly inhibits lymphocyte proliferation induced by mitogens such as PHA PWM PMA and Ca 2 and suppresses Ca 2 /calmodulin-dependent phosphorylation of elongation factor 2 (EF-2) in mouse pancreatic cells In preclinical models Cyclosporin D overcomes Adriamycin resistance in multidrug-resistant ovarian cancer cells and inhibits TPA-induced ear edema and alkaline phosphatase activity in mice Additionally it displays inhibitory effects on the growth of malarial parasites both in vitro and in vivo Cyclosporin D serves as a standard in Cyclosporin A quantification and as a research tool in immunology oncology and antiparasitic studies
Medchemexpress LLC Dodecanedioic acid-d4 | 97543-02-7 | 234.33 | 10 MG
Dodecanedioic acid-d4 is the deuterium labeled version of Dodecanedioic acid. Dodecanedioic acid is an orally active straight-chain dicarboxylic acid that acts as an alternative energy substrate. It can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion, and also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
- Deuterium labeled compound for quantitative tracing during drug development.
- Reduces muscle fatigue during exercise.
- Exhibits blood glucose-lowering activity.
Medchemexpress LLC Sapintoxin D | 80998-07-8 | 99.9% | 10 MG
Sapintoxin D is a fluorescent phorbol ester used to study the activation of protein kinase C (PKC). It functions as a calcium-dependent PKC activator, making it suitable for various research applications in cell biology and biochemistry.
- Fluorescent phorbol ester
- Activates protein kinase C (PKC)
- Calcium-dependent mechanism
- Appears as a white to off-white solid
- High purity of 99.91%
- Soluble in DMSO for in vitro studies
Medchemexpress LLC Chmfl-pi4k-127 | 2377604-81-2 | 99.9% | 402.85 g/mol | C18H15ClN4O3S | 10 MG
CHMFL-PI4K-127 is a potent, selective Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4K) inhibitor provided for research use. It exhibits sub-nanomolar enzymatic potency and cellular antimalarial activity, and is supplied at high chemical purity suitable for in vitro and in vivo studies.
- Potent PfPI4K inhibition (IC50 ~0.9 nM).
- Demonstrated cellular antimalarial activity (EC50 ~25.1 nM).
- High chemical purity for reliable experimental results (>99.9%).
- Available in research-scale quantities for assay development.
- Soluble in DMSO for standard compound handling and dosing.
Medchemexpress LLC Interferon alpha/beta receptor 1 Antibody (YA3833) | 110-130 kDa | 10 UL
This Interferon alpha/beta receptor 1 Antibody (YA3833) is a mouse-derived, non-conjugated IgG1 monoclonal antibody targeting Interferon alpha/beta receptor 1. It forms a heterodimeric receptor with IFNAR2 for type I interferons, activating the JAK-STAT signaling cascade to regulate interferon-responsive genes.
- Mouse-derived monoclonal antibody
- Non-conjugated IgG1 isotype
- Targets interferon alpha/beta receptor 1
- Reacts with human and mouse species
- Suitable for WB, IHC-P, FC, and ELISA applications
- Supplied as a liquid in PBS with 0.05% sodium azide
- Purity is affinity purified
- Store at -20°C for one year; avoid repeated freeze/thaw cycles
![Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy B D glucopyranoside [4 Methylumbelliferyl N acetyl B D glucosaminide], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660605.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy B D glucopyranoside [4 Methylumbelliferyl N acetyl B D glucosaminide], 1 G
Methylumbelliferyl N-acetylglucosaminide (1 g) is a fluorogenic substrate used in enzymatic assays, particularly for detecting the activity of β-glucosaminidases. This compound is widely used in research and diagnostic laboratories for assessing enzyme activity in microbial samples, tissue cultures, and various biochemical processes. The fluorogenic property of this substrate means it generates a detectable fluorescence when cleaved by the enzyme, providing a sensitive and reliable measurement. This 1 g quantity is ideal for routine laboratory assays where the activity of glycosidases, particularly in cell-based systems, is being studied.
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
