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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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Vitamin D binding protein precursor 353-363 is a serum glycoprotein fragment derived from Homo sapiens It is associated with vitamin D binding protein (DBP) a plasma protein that binds vitamin D metabolites and actin monomers mediating transport in the bloodstream and regulation of extracellular actin levels DBP is present on surfaces of various immune cell types including B and T lymphocytes as well as placental cytotrophoblasts Based on these pharmacological properties vitamin D binding protein precursor 353-363 holds research potential in studies of vitamin D metabolism immune regulation and cytoskeletal interactions
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DL- -Hydroxyglutaric acid disodium salt (CAS 40951-21-1) is a small molecule analogue of -hydroxyglutaric acid a metabolite implicated in neurometabolic disorders In humans aberrant accumulation of D- -hydroxyglutaric acid occurs in D-2-hydroxyglutaric aciduria associated with mutations in isocitrate dehydrogenase (IDH) enzymes particularly IDH1 and IDH2 These mutations alter normal metabolic flux leading to overproduction of D- -hydroxyglutaric acid from 2-oxoglutarate In preclinical studies elevated levels of this metabolite are detectable in IDH1-mutant glioma models and non-invasive quantification is feasible via magnetic resonance spectroscopy DL- -Hydroxyglutaric acid disodium salt is utilized in research investigating metabolic dysregulation biomarker development and disease mechanisms linked to IDH mutations and gliomagenesis
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CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. It triggers apoptosis and G2/M cell cycle arrest and demonstrates broad-spectrum cytotoxic action against cancer cell lines. In vitro, it is soluble in DMSO at 100 mg/mL.
Induces apoptosis and G2/M cell cycle arrest
Exhibits cytotoxic activity against HCT-116 cells (IC50 of 5.33 ± 0.69 μM)
Exhibits cytotoxic activity against WI-38 cells (IC50 of 21.69 ± 1.04 μM)
Shows antiproliferative activity against various human cancer cell lines
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