Carbohydrates
Medchemexpress LLC Cdk1/Cyc B-IN-1 | 2459916-56-2 | 98.5% | 353.85 | 5 MG
CDK1/Cyc B-IN-1 is a selective inhibitor of the CDK1/Cyc B complex, exhibiting an IC50 of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest. It demonstrates broad-spectrum cytotoxic activity across various cancer cell lines.
- Selective CDK1/Cyc B complex inhibitor.
- IC50 of 97 nM against CDK1-Cyclin B.
- Triggers apoptosis.
- Induces G2/M cell cycle arrest.
- Exhibits broad-spectrum cytotoxic action against cancer cell lines.
- Shows cytotoxic activity against HCT-116 and WI-38 cells with IC50 values of 5.33 ± 0.69 μM and 21.69 ± 1.04 μM respectively.
Medchemexpress LLC [3,3'-Bipyridine]-5-carboxamide, 6'-chloro-N-methyl-5'-[(phenylsulfonyl)amino]- | 2377604-81-2 | 523747 | C18H15ClN4O3S | 25 MG
CHMFL-PI4K-127 is an orally active, potent, and highly selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor with an IC50 of 0.9 nM. It demonstrates potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM, and exhibits antimalaria efficacy.
- Potent and selective PfPI4K inhibitor.
- Exhibits antimalaria efficacy.
- Orally active compound.
Medchemexpress LLC BET-IN-14 | 2243669-93-2 | C30H37N7O2 | 1 MG
BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM) exhibiting anti-cancer activity. It shows anti-tumor effects against various cancer cell lines, including MM.1S, Ty-82, MV-4-11, and KG-1 cells, with an average IC50 of 174.7 nM after 72 hours. In vivo, BET-IN-14 inhibits tumor growth in MV-4-11 xenograft models.
- Orally active pan BET inhibitor
- Exhibits anti-cancer activity
- Effective against various cancer cell lines (MM.1S, Ty-82, MV-4-11, KG-1)
- Inhibits tumor growth in xenograft models
Medchemexpress LLC (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide | 1147883-03-1 | 99.3% | 265.30 g/mol | C14H19NO4 | 10MG
EPI-589 is a redox-active neuroprotectant under investigation for neurodegenerative disease research; it acts as an oxidoreductase inhibitor and free-radical scavenger with demonstrated blood-brain barrier permeability and oral activity in preclinical studies. The compound is supplied as a light-yellow solid with high reported purity and common small-package options suitable for in vitro and in vivo research.
- Redox-active neuroprotectant for research use.
- Reversible redox cofactor and free-radical scavenger.
- High purity (99.3%).
- Soluble in DMSO at 100 mg/mL (use freshly opened DMSO; ultrasonic assistance may be needed).
- Available in small package sizes suitable for early-stage studies.
- Solid, light yellow appearance facilitating handling and storage.
- Recommended storage: powder at -20 °C (up to 3 years) or 4 °C (up to 2 years); in solution at -80 °C (up to 6 months) or -20 °C (up to 1 month).
Chem-Impex International, Inc. 5-Bromo-4-chloro-3-indolyl-b-D-glucuronide sodium salt | 129541-41-9 | MFCD00135782 | 250MG
5-Bromo-4-chloro-3-indolyl-b-D-glucuronide sodium salt, 129541-41-9, MFCD00135782, 250MG
Medchemexpress LLC D-Iditol | 25878-23-3 | MFCD09951922 | 98.0% | 182.17 g/mol | C6H14O6 | 10 MG
D-Iditol is a fungal metabolite and sugar alcohol that accumulates in galactokinase deficiency. It is supplied as a white to off-white solid with ≥98.0% purity for research use only and is commonly used as an endogenous metabolite reference or reagent in biochemical and metabolic studies.
- High purity: 98.0% (manufacturer specification).
- Molecular weight 182.17 g/mol; formula C6H14O6.
- White to off-white solid suitable for analytical and synthetic applications.
- Stable when stored sealed at 4°C; in solvent: -80°C (6 months) or -20°C (1 month).
- Suitable for biochemical, metabolic, and analytical research workflows.
AdipoGen 3-OH-C5-DL-HSL
Chemical. CAS 148433-24-3. Formula C9H15NO4. MW 201.22. 3-Hydroxy-pentanoyl-DL-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
Medchemexpress LLC [D-Ala2]-GIP (human) | 444073-04-5 | 98.97% | 4983.60 | 25 MG
[D-Ala2]-GIP (human) is a GIP receptor agonist with an EC50 of 630 pM. It improves glucose tolerance and demonstrates neuroprotective activity in an MPTP-induced Parkinson's disease model. Additionally, it enhances cognitive function and hippocampal synaptic plasticity in obese diabetic rats. This product is suitable for research related to type 2 diabetes, Parkinson's disease, and similar conditions.
- Acts as a GIP receptor agonist with an EC50 of 630 pM
- Improves glucose tolerance by stimulating insulin release
- Demonstrates neuroprotective activity in MPTP-induced Parkinson's disease models
- Enhances cognitive function and hippocampal synaptic plasticity in obese diabetic rats
- Attenuates the behavioral phenotype of Parkinson's disease
- Reverses decline in motor ability and reduces muscle stiffness
- Inhibits the increase of MDA levels in the brain
Medchemexpress LLC 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside | 37067-30-4 | 99.95% | 379.36 | 250 MG
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase. The enzyme functionality is assessed by its ability to remove terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from the compound.
- Fluorogenic substrate for N-acetyl-β-D-glucosaminidase
- Assesses enzyme functionality by removing terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues
- White to off-white solid appearance
- Classified as a fluorescent dye and enzyme labeling agent
Medchemexpress LLC Thiazolo[4,5-d]pyrimidine-2(3H)-thione, 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl- | 2459916-56-2 | 98.5% | 353.85 | 25 MG
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. It induces apoptosis and G2/M cell cycle arrest, and exhibits broad-spectrum cytotoxic action against various cancer cell lines.
- Selective inhibitor of the CDK1/Cyc B complex.
- Induces apoptosis and G2/M cell cycle arrest.
- Exhibits broad-spectrum cytotoxic action against cancer cell lines.
- Cytotoxic activity against HCT-116 cells and WI-38 cells.
Medchemexpress LLC 4-Methylumbelliferyl palmitate | 17695-48-6 | 99.2% | 414.59 | 10 MG
4-Methylumbelliferyl palmitate is an excellent fluorophore for measuring acid lipase in human leukocytes. Acidity and solvent have important influence on its fluorescence. It exists mainly as neutral molecular form which can be produced strong fluorescence at 445 nm in near neutral aqueous solutions, and exists mainly as anion form which can be produced stronger fluorescence at 445 nm in weak alkaline solutions.
- Excellent fluorophore for measuring acid lipase in human leukocytes.
- Fluorescence is influenced by acidity and solvent.
- Produces strong fluorescence at 445 nm in near neutral aqueous solutions.
- Produces stronger fluorescence at 445 nm in weak alkaline solutions.
Medchemexpress LLC Integrin alpha 5 bet 50ug | 50ug
ITGA5 is a multifunctional receptor that interacts with multiple ligands such as fibronectin fibrinogen PLA2G2A fibrillin-1 (FBN1) IL1B human metapneumovirus and soluble CD40LG ITGA5 recognizes RGD sequences and mediates cell adhesion through different binding sites Integrin alpha 5 beta 1 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha 5 beta 1 protein expressed by HEK293 with C-Avi C-His labeled tag Integrin alpha 5 beta 1 Protein Human (HEK293 His-Avi) has molecular weight of 100-140 kDa
Medchemexpress LLC OBI-992 drug-linker | 3039487-10-7 | 96.6% | 2173.46 | C106H162FN9O37 | 10 MG
OBI-992 drug-linker is an exatecan-based drug-linker conjugate designed for antibody-drug conjugate (ADC) synthesis. It links the TOP1 inhibitor exatecan to a cleavable linker to enable targeted delivery of the payload; preclinical studies report antitumor activity in mouse and PDX models. Supplied as a solid for research use, the product includes specified purity and storage recommendations for laboratory handling.
- Composed of exatecan linked to a cleavable linker.
- Demonstrated antitumor activity in preclinical models.
- High molecular weight compound suitable for ADC synthesis.
- Provided as a white to yellow solid.
- Purity 96.6%.
- Molecular weight 2173.46.
- Storage: sealed, away from moisture and light; in solvent -80°C for 6 months, -20°C for 1 month.
- Supplied in a 10 mg package for research use.
Medchemexpress LLC 4-Methylumbelliferyl-β-D-glucuronide hydrate | 881005-91-0 | 99.9% | 50 MG
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrate with excitation at 362 nm and emission at 445 nm. It is primarily used for detecting the activity of β-glucuronidase and quantifying *Escherichia coli*.
- Fluorogenic substrate for β-glucuronidase activity detection.
- Detects *Escherichia coli* count.
- Releases 4-methylumbelliferone for enzymatic reactions.
- Soluble in DMSO and H2O.
- Store at 4°C, protected from light.