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TNF-alpha/TNFSF2 protein binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR It induces tumor cell death fever cachexia cell proliferation and cell differentiation It also causes insulin resistance and GKAP42 protein degradation in adipocytes Additionally it plays a role in angiogenesis osteoclastogenesis and IL12 production in dendritic cells TNF-alpha/TNFSF2 Protein Cynomolgus (N-His) is the recombinant cynomolgus-derived TNF-alpha/TNFSF2 protein expressed by E coli with N-6 His labeled tag
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2-hexyl-4-Pentynoic Acid (CAS 96017-59-3) is a valproic acid derivative that functions as a histone deacetylase (HDAC) inhibitor exhibiting an IC50 of 13 M HDACs regulate gene expression by removing acetyl groups from histones promoting chromatin condensation and transcriptional repression In cerebellar granule cells 2-hexyl-4-Pentynoic Acid increases acetylated histone H3 levels in a dose-dependent manner and enhances HSP70-1a/1b mRNA expression At 50 100 M it significantly elevates Ac-H3 levels beyond those achieved with valproic acid and provides complete protection against glutamate-induced cell death indicating its utility in neuroprotection and epigenetic research
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trans-2-Methyl-2-pentenoic Acid ((E)-2-Methyl-2-pentenoic Acid strawberry acid) has a sweet berry-like aroma and flavor and is widely used in food flavor
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