Nucleosides and Analogues
eMolecules 990-91-0 | Tetrabenzyl Pyrophosphate | AA Blocks LLC | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Tetrabenzyl Pyrophosphate | AA Blocks LLC | 990-91-0 | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10mM (in 1mL DMSO)
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 100mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 5mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC Adenosine-13C5 | 159496-13-6 | 99.9% | 272.20 | C10H13N5O4 (five 13C atoms) | 10 MG
Adenosine-13C5 is a stable isotope-labeled adenosine supplied as a powdered research reagent for use as an internal standard or tracer in mass spectrometry and metabolic studies. It contains five 13C-labeled carbons, has a molecular weight of 272.20, and is typically supplied with high purity for quantitative analysis.
- Stable isotope-labeled internal standard for quantitative LC-MS/MS.
- Five 13C labels produce a clear mass shift for tracer studies.
- High purity (99.9%) supports accurate quantitation.
- Supplied as a powder suitable for long-term storage under frozen conditions.
- Available in small mg-scale quantities for analytical applications.
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.17% | 512.15 | 25 MG
Inosine 5′-diphosphate sodium is a purine ribonucleoside 5′-diphosphate with inosine as the nucleobase. It can participate in intracellular energy metabolism and signal transduction processes. This product is for research use only.
- Purine ribonucleoside
- Involved in intracellular energy metabolism
- Participates in signal transduction processes
- Useful for research in respiratory and metabolic diseases
- Classified as a nucleotide analog and endogenous metabolite
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 g/mol | C22H29N5O9P2 | 5 MG
Motesanib diphosphate is the diphosphate salt of motesanib, an ATP-competitive inhibitor of VEGFR1/2/3 and c-Kit, supplied for laboratory research and analytical applications.
- Potent ATP-competitive inhibitor of VEGFR1/2/3 and c-Kit.
- Molecular formula: C22H29N5O9P2.
- Molecular weight: 569.44 g/mol.
- Pack size: 5 mg.
- Solubility: DMSO ≥ 110 mg/mL; H2O 5 mg/mL (with ultrasonic warming).
- Storage: 4°C sealed; in solvent -80°C (6 months), -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC Adenosine 5'-O-(2-thiodiphosphate) trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | C10H12Li3N5O9P2S | 10MG
ADP-β-S trilithium is the trilithium salt of adenosine 5'-β-thiodiphosphate, used in research as a P2Y12 receptor activator. It is supplied as a white to off-white solid (CAS 73536-95-5) with listed purity ~94.9% and molecular formula C10H12Li3N5O9P2S. Store sealed and away from moisture; in solution store at -80°C for long-term stability.
- Activator of P2Y12 receptor in cellular assays.
- Upregulates IL-1β and IL-6 production in microglial models.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation in relevant studies.
- Provided as a solid suitable for preparation of assay solutions.
- Stable under recommended sealed, low-temperature storage conditions.
Medchemexpress LLC Adenosine 5'-β-thiodiphosphate trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | 461.07 g·mol⁻¹ | C10H12Li3N5O9P2S | 5 MG
ADP-β-S trilithium is the trilithium salt form of adenosine 5'-β-thiodiphosphate used as a research reagent to activate P2Y12 receptors and study purinergic signaling and inflammatory pathways. It modulates cytokine production and NF-κB/NLRP3 signaling, and is provided as a dry powder for laboratory use.
- Activates P2Y12 receptor to modulate purinergic signaling.
- Increases IL-1β and IL-6 production in microglial cells.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation.
- Supplied with stated purity and molecular data for experimental planning.
- Suitable for biochemical and cellular assays requiring receptor activation.
TARGETMOL CHEMICALS INC ADENOSINE ANTAGONIST-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine antagonist-1 acts as an adenosine A3 receptor (AA3R) antagonist. purity: 99%
Medchemexpress LLC Tenofovir diphosphate disodium | 2738719-07-6 | 99.42% | 491.14 | 1 MG
Tenofovir diphosphate disodium is an antiretroviral agent primarily used for AIDS research. It acts as an inhibitor of HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). This compound exhibits minimal inhibitory effect on eukaryotic DNA replication in vitro.
- Antiretroviral agent
- Inhibits HIV reverse transcriptase DNA and RNA
- Used for AIDS research
- Minimal inhibitory effect on eukaryotic DNA replication in vitro
Medchemexpress LLC Acyclovir triphosphate sodium | 221119-43-3 | 99.7% | C8H14N5O12P3.xNa | 25 MG
Acyclovir triphosphate sodium (AcycloGTP sodium) is a derivative of Acyclovir that functions as an inhibitor of viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). This compound is also recognized as an inhibitor of HIV-1 reverse transcriptase, ultimately leading to the termination of viral DNA synthesis. It is intended for research use only.
- Competitively inhibits viral DNA polymerase.
- Acts as an analog to deoxyguanosine triphosphate (dGTP).
- Inhibits HIV-1 reverse transcriptase.
- Causes termination of viral DNA synthesis.
- Available for research purposes.
Medchemexpress LLC Guanosine 5'-triphosphate (trisodium salt) | 36051-31-7 | 95.0% | 50 MG
Guanosine 5'-triphosphate (trisodium salt) is a G protein signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. It can promote myogenic cell differentiation and induce human myogenic precursor cells to release exosomes. This product is for research use only and holds promise for research in biosynthesis and skeletal muscle regeneration.
- Acts as a G protein signaling activator
- Functions as a high-energy precursor in the biosynthesis of DNA and RNA nucleotide units
- Promotes myogenic cell differentiation by upregulating miRNA and myogenic regulatory factor expression
- Induces human myogenic precursor cells to release exosomes containing guanosine molecules
Medchemexpress LLC GTP-14564 | 34823-86-4 | 99.9% | 234.25 | 10 MG
GTP-14564 is a tyrosine kinase inhibitor that targets internal tandem duplication (ITD) and FLT3. It inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Tyrosine kinase inhibitor
- Targets ITD and FLT3
- Inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells
- Available in various quantities
- Available as solid or in solution (10 mM in DMSO)
- Off-white to yellow solid appearance
- For research use only
- Has a data sheet, COA, SDS, and handling instructions available
Medchemexpress LLC Alpha guanosine | 15398-66-0 | 96.0% | 283.24 g/mol | C10H13N5O5 | 10 MG
Alpha guanosine is a purine nucleoside analog used in biochemical and pharmacological research to study nucleoside metabolism and antimetabolite activity. The product is supplied as a purified powder with documented physicochemical properties, recommended storage conditions, and solubility information to support preparation of stable stock solutions for laboratory use.
- Purity: 95.96%
- Molecular formula: C10H13N5O5
- Molecular weight: 283.24 g/mol
- Soluble in DMSO at 12.5 mg/mL with ultrasonic warming to 60°C
- Powder recommended storage: -20°C, stable for up to 3 years
- In-solution stability: -80°C for 6 months, -20°C for 1 month
- Available in small milligram pack sizes for research applications