Nucleosides and Analogues
Chemscene ChemScene | Gemcitabine (hydrochloride) | 25G | CS-0755 | 0.98 | 122111-03-9| MFCD01735988 | 299.66
ChemScene | Gemcitabine (hydrochloride) | 25G | CS-0755 | 0.98 | 122111-03-9| MFCD01735988 | 299.66
Apexbio Technology LLC GTP Solution (100 mM) 1mL
GTP also known as Guanosine-5 -triphosphate can be utilized in various molecular biology applications such as in vitro transcription RNA amplification and siRNA synthesis Additionally GTP plays a critical regulatory role in signal transduction as a phosphate or pyrophosphate messenger it activates G-proteins which subsequently initiate protein kinase-mediated signaling cascades thus influencing cellular behaviors including cell proliferation and differentiation GTP also serves as a high-energy nucleotide precursor participating in enzymatic synthesis processes of DNA and RNA This product is prepared from GTP trisodium salt with purity 99% (HPLC) as a clear colorless aqueous solution at a concentration of 100 mM and pH (25 C) of 7 0 0 1 free from DNase and RNase contamination
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10mM (in 1mL DMSO)
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Cayman Chemical 5-Formyl-2'-deoxyuridine, Purity: ≥95%, CAS: 4494-26-2, 10 mg
A nucleoside derivative; inhibits the proliferation of BHK-21 cells and Ehrlich ascites tumor cells (IC50s = 4 and 6 µM, respectively); reduces virus yield in psuedorabies-infected BHK-21 cells at 1 mM; a product of oxidative DNA damage in vitro
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10g
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Apexbio Technology LLC ATP(Synonyms: Adenosine triphosphate, Adenosine 5'-triphosphate, Adenosine-5'-triphosphoric acid), 100mg, CAS: 56-65-5.
Adenosine triphosphate (ATP CAS 56-65-5) is a nucleoside triphosphate comprising adenine linked to ribose with three phosphate groups esterified sequentially ATP primarily functions as a universal energy carrier in cellular metabolism transferring phosphate groups to facilitate enzymatic reactions and drive biological activities Additionally ATP acts extracellularly as a neurotransmitter and signaling molecule binding purinergic receptors to modulate physiological responses such as neurotransmission vascular tone inflammation and immune cell function Due to its versatile biological roles ATP is extensively employed in biomedical research investigating metabolic pathways receptor signaling dynamics and cellular energetics
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 100mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Accela Chembio Inc THYMIDINE | 25G | 50-89-5 | MFCD00006537 | 98% | RETEST PERIOD: 1800DAYS | LIGHT SENSITIVE/+4c
THYMIDINE | 25G | 50-89-5 | MFCD00006537 | 98% | RETEST PERIOD: 1800DAYS | LIGHT SENSITIVE/+4c
Cayman Chemical N6-benzoyl-2'-Deoxyadenosine, Purity: ≥95%, CAS: 4546-72-9, 1 g
A nucleoside building block; has been used in the synthesis of various oligonucleotides
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 100mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Apexbio Technology LLC Kinetin riboside 4338-47-0 50mg
Kinetin riboside (CAS 4338-47-0) is a cytokinin analog known to induce apoptosis in cancer cells by modulating intracellular signaling pathways Experimental studies have demonstrated that it inhibits the proliferation of HCT-15 colorectal cancer cells with an IC50 value of 2 5 M indicating pronounced activity at low micromolar concentrations Owing to its defined mechanism of action Kinetin riboside is widely utilized in cancer biology and targeted therapy research to investigate its potential roles in cancer treatment
Chem-Impex International, Inc. (E)-5-(2-Bromovinyl)-2'-deoxyuridine | MFCD00058585 | 1G
(E)-5-(2-Bromovinyl)-2'-deoxyuridine, MFCD00058585, 1G
Cayman Chemical 6-Chloropurine Riboside, Purity: ≥98%, CAS: 5399-87-1, 1 g
A nucleoside precursor; used in the synthesis of adenosine or N6-benzyladenosine derivatives with anticancer or antiparasitic activities in vitro
Cayman Chemical 5'-chloro-5'-Deoxyadenosine (hydrate), Purity: ≥98%, CAS: 698999-09-6, 1 g
A nucleoside analog used as a substrate in the biosynthesis of the anticancer agent salinosporamide A