Nucleosides and Analogues
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 5mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Abcam Iodotubercidin, adenosine kinase inhibitor, 5MG
MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC₅₀ = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC L-Adenosine | 3080-29-3 | MFCD01075784 | 99.8% | 267.25 | C10H13N5O4 | 10 MG
L-Adenosine is the L-enantiomer of adenosine, a metabolically stable nucleoside analog used as a research probe. It exhibits weak inhibitory activity against adenosine deaminase (ADA) and is used to study adenosine uptake and accumulation.
- CAS number 3080-29-3.
- Molecular formula C10H13N5O4; molecular weight 267.25.
- Purity 99.82% (typical).
- Physical form solid, white to off-white.
- Storage: 4°C, protect from light; in solvent -80°C for 6 months, -20°C for 1 month.
- Reported Ki for ADA: 385 μM.
Medchemexpress LLC L-adenosine | 3080-29-3 | MFCD01075784 | 99.8% | 267.25 g/mol | C10H13N5O4 | 100 MG
L-Adenosine is an enantiomeric nucleoside used as a biochemical probe for adenosine uptake and metabolism. It displays weak adenosine deaminase (ADA) inhibitory activity and is supplied in high-purity forms for laboratory research.
- High purity (≈99.8%).
- Molecular weight 267.25 g/mol.
- CAS number 3080-29-3.
- Available as solid and 10 mM DMSO solution formats.
- Suitable for biochemical, uptake, and metabolism studies.
Medchemexpress LLC Adenosine monophosphate | 61-19-8 | 99.8% | C10H14N5O7P | 1 ML
Adenosine monophosphate (AMP) is an adenosine A1 receptor agonist and a key cellular metabolite involved in regulating energy homeostasis and signal transduction. It demonstrates significant antiviral activity against HSV-1 and HSV-2.
- Acts as an adenosine A1 receptor agonist
- Demonstrates significant antiviral activity against HSV-1 and HSV-2
- Functions as a key cellular metabolite regulating energy homeostasis and signal transduction
- Shows negligible cell toxicity at 25 to 400 μM in RAW264.7 cells
- Significantly attenuates mRNA expression of TNF-α and IL-6 in RAW264.7 cells
- Reduces recruitment of NF-κB p65 to TNF-α, IL-6, and IL-1β gene promoters
- Increases hepatic adenosine levels in C57BL/6J mice
- Improves survival rate and lowers serum AST and ALT levels in treated mice
- Attenuates necrosis and reduces infiltration of inflammatory cells in vivo
Cambridge Isotope Laboratories Guanosine phosphoramidite (U-15N5 98%) CP 95% 50 mg
Guanosine phosphoramidite (U-15N5 98%) CP 95% 50 mg
Medchemexpress LLC 6H-purin-6-one, 2-amino-1,9-dihydro-9-β-l-ribofuranosyl- | 26578-09-6 | 98.0% | 283.24 | 50 MG
L-Guanosine is the L-configuration of Guanosine, a purine nucleoside with anti-herpesvirus activity. It can be utilized in the preparation of supramolecular hydrogel.
- L-configuration of guanosine
- Purine nucleoside with anti-herpesvirus activity
- Utilized in the preparation of supramolecular hydrogel
Medchemexpress LLC Adenosine receptor antagonist 3 | 2400864-80-2 | 97.1% | C16H14N6S | 10MG
Adenosine receptor antagonist 3 is a small-molecule research compound that antagonizes adenosine receptors and is used in in vitro pharmacology and GPCR/G protein signaling studies. Supplied as a light-yellow solid and as a 10 mM solution in DMSO, it has a reported purity of 97.1% and molecular formula C16H14N6S.
