Nucleosides and Analogues
eMolecules 990-91-0 | Tetrabenzyl Pyrophosphate | AA Blocks LLC | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 25g | 436007792
Tetrabenzyl Pyrophosphate | AA Blocks LLC | 990-91-0 | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 25g | 436007792
Medchemexpress LLC 7-Methylguanosine 5'-diphosphate sodium | 104809-16-7 | 97.1% | C11H16N5NaO11P2 | 1 MG
7-Methylguanosine 5'-diphosphate sodium is a cap analog used in the synthesis of mRNA cap analogues.
- Inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA.
- Is a substrate for T. brucei mRNA decapping enzyme (TbDcp2) which cleaves it from capped RNA to generate pRNA.
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 g/mol | C22H29N5O9P2 | 100 MG
Motesanib diphosphate is the diphosphate salt of a small-molecule ATP-competitive inhibitor of vascular endothelial growth factor receptors (VEGFR1/2/3). It is supplied as a research-grade analytical standard for biochemical assays, pathway studies, and method development. The compound should be stored sealed and protected from moisture; in solvent, stability is -80°C for up to six months and -20°C for up to one month.
- High purity (~99.9%).
- Potent VEGFR1/2/3 inhibition with IC50s 2-6 nM.
- Molecular formula C22H29N5O9P2, molecular weight 569.44 g/mol.
- Suitable for biochemical assays and analytical method development.
- Storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.2% | 512.15 | 50 MG
Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate that features inosine as its nucleobase. This compound is known for its role in intracellular energy metabolism and signal transduction processes.
- A purine ribonucleoside 5'-diphosphate
- Inosine is the nucleobase
- Participates in intracellular energy metabolism
- Involved in signal transduction processes
- Relevant to respiratory disease research
- Applicable to metabolic or endocrine disease studies
- Used in pulmonary disease research
- Investigated in lung fibrosis studies
- Can be classified as an oligonucleotide
- Functions as a nucleotide analog
- Related to inosine compounds
- Identified as a nucleoside
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.17% | 512.15 | 500 MG
Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate with inosine as the nucleobase. It participates in intracellular energy metabolism and signal transduction processes.
- Purine ribonucleoside 5'-diphosphate
- Contains inosine as the nucleobase
- Participates in intracellular energy metabolism
- Involved in signal transduction processes
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | MFCD16627994 | 100.0% | 681.49 g·mol^-1 | C26H32F3N3O11P2 | 10 MG
Sonidegib diphosphate is the diphosphate salt of sonidegib, a potent and selective Smoothened (Smo) antagonist used in research to inhibit Hedgehog pathway signaling. It shows low-nanomolar binding potency in Smo assays and is supplied for laboratory use with supporting datasheet and safety documents.
- Potent Smo antagonist with low-nanomolar binding (mouse 1.3 nM; human 2.5 nM).
- Diphosphate salt form suitable for aqueous assay conditions.
- Supplied as a 10 mg vial for research use.
- Molecular weight 681.49 g·mol^-1; formula C26H32F3N3O11P2.
- Storage: sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 25mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Medchemexpress LLC 7-methylguanosine 5'-diphosphate sodium | 104809-16-7 | 97.1% | 479.21 g·mol⁻¹ | C11H16N5NaO11P2 | 5 MG
7-Methylguanosine 5'-diphosphate sodium (m7GDP sodium) is a nucleotide cap analog used in RNA and mRNA research. Supplied as a solid sodium salt with high purity, it serves as a reagent or standard in studies of mRNA capping, cap-binding proteins, and enzymatic assays involving guanine nucleotides.
- Used as a cap analog in mRNA cap-analogue synthesis and biochemical assays.
- Supplied as a solid sodium salt suitable for laboratory use.
- High purity (97.1%) for consistent experimental performance.
- Available in small research pack sizes for low-quantity applications.
- Store sealed at -20°C; in solution, store at -80°C for longer-term stability.
TARGETMOL CHEMICALS INC ADENOSINE AMINE CONGENER 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor. purity: 98%
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 10mM (in 1mL DMSO)
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Medchemexpress LLC NAD P H-flavin reduc 20ug
NAD(P)H-flavin reductase is a recombinant His-tagged enzyme expressed in E. coli that catalyzes the reduction of soluble flavins using NADH or NADPH. Supplied as a lyophilized powder formulated in PBS with trehalose, it is intended for enzymatic assays and biochemical studies requiring a reliable flavin reductase reference reagent.
- Recombinant enzyme with N-terminal His tag.
- Catalyzes reduction of soluble flavins using NADH or NADPH.
- Supplied lyophilized from PBS with 6% trehalose.
- Purity greater than 90% by reducing SDS-PAGE.
- Low endotoxin level (<1 EU/μg).
- Stable when stored at -20°C; aliquot and freeze for long-term storage.
Apexbio Technology LLC Flavin adenine dinucleotide disodium 84366-81-4 100mg
Flavin adenine dinucleotide disodium (CAS 84366-81-4) is an oxidoreductive cofactor widely utilized in biomedical research As a prosthetic group of flavoproteins it mediates reversible electron transfer reactions integral to cellular energy metabolism mitochondrial respiration and biological oxidation processes This compound is frequently employed to investigate the catalytic mechanisms of flavin-dependent enzymes such as dehydrogenases and oxidases Additionally it serves as a valuable tool in elucidating metabolic pathways and studying mitochondrial dysfunction associated with various pathological conditions
Apexbio Technology LLC Flavin adenine dinucleotide disodium 84366-81-4 500mg
Flavin adenine dinucleotide disodium (CAS 84366-81-4) is an oxidoreductive cofactor widely utilized in biomedical research As a prosthetic group of flavoproteins it mediates reversible electron transfer reactions integral to cellular energy metabolism mitochondrial respiration and biological oxidation processes This compound is frequently employed to investigate the catalytic mechanisms of flavin-dependent enzymes such as dehydrogenases and oxidases Additionally it serves as a valuable tool in elucidating metabolic pathways and studying mitochondrial dysfunction associated with various pathological conditions
Medchemexpress LLC 6-O-Methyl Guanosine | 7803-88-5 | 99.7% | 297.27 | 10 MG
6-O-Methyl Guanosine is a modified nucleoside that inhibits colony-forming ability in a malignant xeroderma pigmentosum cell line.
- Functions as a modified nucleoside
- Exhibits inhibition of colony-forming ability
- Relevant for nucleoside antimetabolite/analog research
