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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
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Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 uM. Purity 99.55%
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A deoxyribonucleoside, may be used by some cells as an energy source under energy stress conditions and to affect cAMP levels. It is used in comparison studies of the functions of adenosine analogues on various biological processes. Specifications:Ultra Pure GradeEM (259nm, phosphate buffer, pH 7.0): >14,500Appearance: White crystalline powderChEBI : Not available.Crystal_Structure : Not available.InChI : Not available.InChIKey : Not available.Melting Point: 187-189 °CRTECS Number: AU7358600
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 5'-Fluoro-5'-deoxyadenosine (5'-Fluoro-5'-deoxy-adenosine) is utilized commonly as a tool for studying the Actinomycete bacterium Streptomyces cattleya. purity: 97%
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Cordycepin (73-03-0) is a small-molecule inhibitor targeting pro-inflammatory cytokines such as IL-1 IL-6 and TNF- It is designed to inhibit inflammatory signaling pathways thereby regulating immune and inflammatory responses Cordycepin exerts its biological activity primarily through interference with RNA synthesis by incorporation into RNA chains leading to premature termination and inhibition of protein translation In cell-based studies cordycepin demonstrates inhibitory activity with IC50 values in the low micromolar range (approximately 5-15 M) depending on experimental conditions and cell models Based on these pharmacological properties cordycepin holds research potential in inflammation regulation immune-response modulation tuberculosis infection modeling and RNA transcription studies
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A deoxyribonucleoside, may be used by some cells as an energy source under energy stress conditions and to affect cAMP levels. It is used in comparison studies of the functions of adenosine analogues on various biological processes. Specifications:Ultra Pure GradeEM (259nm, phosphate buffer, pH 7.0): >14,500Appearance: White crystalline powderChEBI : Not available.Crystal_Structure : Not available.InChI : Not available.InChIKey : Not available.Melting Point: 187-189 °CRTECS Number: AU7358600
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Also available in 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. 5'-Amino-5'-deoxyadenosine (NH2dAdo) is an adenosine kinase inhibitor targeting malignant tumors of the inert lymphatic system with antitumor and anticancer effects. Its mechanism is mediated by the inhibition of DNA synthesis and induction of apoptosis. Purity 95.55%
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2'-Deoxyadenosine monohydrate-13C10,15N5 is the 13C and 15N labeled 2'-Deoxyadenosine monohydrate. 2'-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. It also inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. It activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) and the growth of various cells. It has an anticancer effect on colon cancer.
This compound can be used as a tracer.
This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. It causes rapid cell death for the majority of cancer cell lines tested with IC50s between 0.7-2.9 μM. In A549 lung cancer cell-based mouse xenograft studies, it decreases tumor growth rate and increases telomere dysfunction in tumor cells in vivo.
Nucleoside analogue
Incorporated into de novo-synthesized telomeres by telomerase
Results in rapid cell death for the vast majority of cancer cell lines tested with IC50s of between 0.7-2.9 μM
Causes a decrease of the tumor growth rate in A549 lung cancer cell-based mouse xenograft studies
Increases telomere dysfunction in tumor cells in vivo
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