c-di-AMP diammonium is a STING agonist that activates the TBK3-IRF3 signaling pathway, triggering the production of type I IFN and TNF. It also acts as a bacterial second messenger, regulating cell growth, survival, and virulence in Gram-positive bacteria and influencing host immune response. Furthermore, it serves as a potent mucosal adjuvant, stimulating both humoral and cellular responses.
- Activates the TBK3-IRF3 signaling pathway.
- Triggers the production of type I IFN and TNF.
- Regulates cell growth, survival, and virulence in Gram-positive bacteria.
- Influences host immune response.
- Potent mucosal adjuvant, stimulating both humoral and cellular responses.